The University of Louisville baseball team used an eight-run sixth inning Tuesday night to push past Indiana University 9-2, capping the Cardinals’ best regular-season home campaign in the modern era, finishing undefeated in midweek games and ending a five-game losing streak to the Hoosiers.

Louisville improved to 43-10 overall and 33-1 at Jim Patterson Stadium — the best home record in the country this season and one that positions U of L to have its best season at home since it went 15-0 in all games in 1957.

The Cards wound up 13-0 in midweek games this year.

“Man, that’s unheard of,” coach Dan McDonnell said of the perfect midweek mark. “That’s not something you ever talk about. I don’t think you ever expect it. Midweek baseball is challenging. Usually it’s younger arms. Sometimes guys are coming out of class. Sometimes you are on a bus for two or three hours, and you’re pulling up to a stadium and hustling to play. There’s so much parity in college baseball, and I tip my cap to this group. It obviously started with Kade McClure and how consistent he was on the mound.”

In chilly, drizzly conditions, regular midweek starter McClure (11-0) struck out a career-high 10 batters in six innings, becoming only the second 11-game winner in NCAA Division I this season and moving ahead of his 10-win teammates Brendan McKay and Drew Harrington for the U of L lead.

Supported by a wet crowd of 1,880, the Cards, No. 5 in the USA TODAY coaches’ poll, won their sixth straight game and their 13th in the last 14.

“To go 33-1 at home is unbelievable, and to not lose a midweek start is awesome,” said McClure, who could start Louisville’s first game in the ACC tournament next week. “I came into this year just hoping to play more than I did last year, so I’m happy where it ended up.”

Indiana got on the board first with Craig Dedelow’s two-out, two-RBI double in the fifth, but Louisville did its damage in the sixth.

McKay and Danny Rosenbaum each had two-run doubles and Devin Hairston, Corey Ray and Solak also had scoring hits in an inning in which Louisville brought 12 men to the plate and got seven hits off three IU pitchers.

Luke Stephenson (1-2) took the loss, charged with four runs in 1 2/3 innings as the Hoosiers lost to U of L for the first time since the 2013 regular season.

Hairston added an RBI single in the eighth, and Ray finished with three hits.

“To put up a big crooked number against a good pitching staff,” McDonnell said, “that shows you the type of hitters we have and the maturity that they have that they were able to string together a big inning.

The Cards, who are No. 2 nationally in the Ratings Percentage Index, are well-positioned for a top-eight national seed. If they get one, they would be guaranteed to host the NCAA regional and super-regional rounds. Given Louisville’s exceptional record at home, it probably will take a major effort from any opponent to prevent U of L making it back to the College World Series.

“We’re not going to take anyone for granted, but I wouldn’t want to be an opposing team coming in here for regionals or super-regionals,” McClure said. “With the fans behind us, the home-field advantage is just huge, and the record shows we don’t lose at home.”

The Cards will finish the regular season with a three-game series at Wake Forest, turning their sights toward trying to stay ahead of Florida State for the ACC Atlantic Division title.

U of L (.704) leads FSU (15-8, .652) in ACC winning percentage. The Seminoles, who have played fewer games than U of L due to weather cancellations, will host Coastal Division leader Miami (40-9, 19-6, .760) for three games starting Thursday.

Any combination of two total U of L wins or FSU losses will give the Cards the title. U of L also could finish ahead of the Hurricanes (19-6, .760) if the Cards sweep Wake and Miami loses twice at FSU.

IU (31-19), which entered the game No. 96 in the RPI, missed a chance to help its NCAA tournament resume. The Hoosiers, who are coached by former U of L assistant Chris Lemonis, will wrap up the regular season with three games at Nebraska that could help decide the Big Ten race. The Hoosiers are 15-6 (.714) in the league, behind only Minnesota (15-5, .750).

“The big inning was the ballgame, and I thought Kade was really good,” Lemonis said. “He kept us off, and once you get that offense of theirs rolling, it’s hard to stop. … We’re kind of leaving (the loss) here in the locker room. We’re flying (Wednesday) to Nebraska to play for a Big Ten championship, and we’re pretty excited about that.

“We just weren’t very good tonight. Tip your hat to Louisville. They were really good. … As a former coach, you love to see where the program’s at and the level of play. I think that if it’s not the best team in the country, it’s one of them.”